Patents

Patents of Daniel L. Comins

1. Daniel L. Comins and Matthew F. Baevsky, “Intermediates and Method of Making Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,162,532 (1992).

2. Daniel L. Comins and Matthew F. Baevsky, “Camptothecin Intermediates and Method of Making Camptothecin Intermediates,” U.S. Patent No. 5,191,082 (1993).

3. Daniel L. Comins and Matthew F. Baevsky, “Camptothecin Intermediates and Method of Making Same,” U.S. Patent No. 5,200,524 (1993).

4. Daniel L. Comins and Matthew F. Baevsky, “Method of Making [Asymmetric] Camptothecin and Camptothecin Analogs”, U.S. Patent No. 5,212,317 (1993).

5. Daniel L. Comins and Matthew F. Baevsky, “Alkylpyridone DE Ring Intermediates Useful for the Manufacture of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,243,050 (1993).

6. Daniel L. Comins and Matthew F. Baevsky, “Method of Making Intermediates Useful for the Manufacture of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,247,089 (1993).

7. Daniel L. Comins and Matthew F. Baevsky, “Alkoxymethylpyridine D-Ring Intermediates Useful for the synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,254,690 (1993).

8. Daniel L. Comins and Matthew F. Baevsky, “Synthesis of Optically Pure D, E Ring Intermediates Useful for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,258,516 (1993).

9. Daniel L. Comins and James M. Salvador, “Cycloalkyl-Based Chiral Auxiliaries and Method of Making the Same,” U.S. Patent No. 5,262,571 (1993).

10. Daniel L. Comins and Matthew F. Baevsky, “D Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,262,579 (1993).

11. Daniel L. Comins and Matthew F. Baevsky, “Process for Making DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,315,007 (1994).

12. Daniel L. Comins and Matthew F. Baevsky, “Pyridinecarboxaldehyde D-Ring Intermediates Useful for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,321,140 (1994).

13. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,395,939 (1995).

14. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,428,166 (1995).

15. Daniel L. Comins, “14-Halo-Camptothecins,” U.S. Patent No. 5,459,269 (1995).

16. Daniel L. Comins and Matthew F. Baevsky, “Camptothecin Intermediates and Method of Making Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,475,108 (1995).

17. Daniel L. Comins and Matthew F. Baevsky, “Method of Making Intermediates for Camptothecin and its Analogs,” U.S. Patent No. 5,478,943 (1995).

18. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin Analogs,” U.S. Patent No. 5,486,615 (1996).

19. Daniel L. Comins, “Method of Making Asymmetric DE Ring Intermediates for the Synthesis of Camptothecin and Camptothecin Analogs,” U.S. Patent No. 5,496,952 (1996).

20. Daniel L. Comins and Matthew F. Baevsky, “Method of Making Camptothecin and Camptothecin Analogs,” Canadian Patent No. 2,112,351(1998).

21. Francis G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, “Preparation of Camptothecin Derivative by Intramolecular Cyclisation,” U.S. Patent No. 6,063,923 (2000).

22. Frances G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, “Preparation of a Camptothecin Derivative by Intramolecular Cyclization,” U.S. Patent No. 6,462,196 (2002).

23. Daniel L. Comins and Shenlin Huang, “A Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No. 6,534,656 (2003).

24. Frances G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, “Preparation of a Camptothecin Derivative by Intramolecular Cyclization,” U.S. Patent No. 6,559,309 (2003).

25. Daniel L. Comins and Shenlin Huang, “Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No.: 6,706,884 (2004).

26. Daniel L. Comins and Shenlin Huang, “Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No. 6,855,825 (2005).

27. Daniel L. Comins and Shenlin Huang, “Short Synthesis of Pyridine-Based Pharmaceutical Intermediates,” U.S. Patent No. 6,987,189 (2006).

28. Daniel L. Comins and Emilie Despagnet, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 6,995,265 (2006).

29. Comins, Daniel L., Florence C. Février, and Emilie Despagnet, “Regioselective Halogenation of Nicotine and Substituted Nicotines,” U.S. Patent No.: 7,067,672 (2006).

30. Laura S. King, Emilie Despagnet and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No.: 7,112,678 (2006).

31. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No.: 7,132,545 (2006).

32. Daniel L. Comins, Florence Février, and Emilie Despagnet Smith, “Regioselective Halogenation of Nicotine and Substituted Nicotines,” U.S. Patent No.: 7,179,917 (2007).

33. Laura S. King, Emilie Smith, and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No.: 7,304,160 (2007).

34. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 7,361,768 (2008).

35. Daniel L. Comins, Florence C. Février, and Emilie D. Smith, “Regioselective Halogenation of Nicotine and Substituted Nicotines,” U.S. Patent No. 7,501,520 (2009).

36. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 7,553,968 (2009).

37. Laura S. King, Emilie D. Smith, and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No. 7,671,209 (2010).

38. Daniel L. Comins, Florence C. Février, and Pauline Ondachi, “Synthesis and Regioselective Substitution of 6-Halo- and 6-Alkoxy Nicotine Derivatives,” U.S. Patent No. 7,820,826 (2010).

39. Laura S. King, Emilie D. Smith, and Daniel L. Comins, “Regiospecific Synthesis of Nicotine Derivatives,” U.S. Patent No. 7,875,724 (2011).

40. Daniel L. Comins and Emilie D. Smith, “Synthesis of Nicotine Derivatives from Nicotine,” U.S. Patent No. 7,888,512 (2011).