1990 – 1999

  1. Daniel L. Comins and Michael O. Killpack, “Lithiation of Methoxypyridines Directed by a‑Amino Alkoxides,” J. Org. Chem., 1990, 55, 69.

 

  1. Daniel L. Comins and Young Chan Myoung, “Synthesis and Synthetic Utility of 1‑Acyl‑5‑(trialkylsilyl)‑ 1,2‑dihydropyridines. Synthesis of (±)‑Elaeokanine A,” J. Org. Chem., 1990, 55, 292.

 

  1. Daniel L. Comins, R. Richard Goehring, Sajan P. Joseph and Sean O’Connor, “Asymmetric Synthesis of 2‑Alkyl(Aryl)- ‑2,3‑dihydro‑4‑pyridones by Addition of Grignard Reagents to Chiral 1‑Acyl‑4‑methoxy­pyridinium Salts,” Org. Chem., 1990, 55, 2574.

 

  1. Phirtu Singh, Daniel L. Comins, and Michael O. Killpack, “Crystal Structure of (‑)‑1‑((1R,2S,5R)‑8‑Phenylmenthoxy- carbonyl)‑(S)‑2‑triphenylsilyl‑2,3‑dihydro‑4‑pyridone,” Acta Cryst., 1990, C46, 1955.

 

  1. Daniel L. Comins and Michael O. Killpack, “Pyridine Synthesis Via Anodic Oxidation of 1‑Acyldihydropyridines,” Heterocycles, 1990, 31, 2025.

 

  1. Daniel L. Comins and Michael A. Weglarz, “Stereocontrolled Preparation of cis‑ and trans‑2,6‑Dialkylpiperidines via 1‑Acyldihydropyridine Intermediates. Synthesis of (±)‑Solenopsin A and (±)‑Dihydropinidine,” J. Org. Chem., 1991,

        56, 2506.

 

  1. Daniel L. Comins and Mohamed M. Badawi, “Nucleophilic Addition to Homochiral N‑Acylisoquinolinium Salts.

Asymmetric Synthesis of (+)‑Carnegine,” Heterocycles., 1991, 32, 1869.

 

  1. Daniel L. Comins and Mohamed M. Badawi, “Asymmetric Pictet‑Spengler Synthesis of Tetrahydroisoquinolines.

An Enantioselective Synthesis of (‑)‑Laudanosine,” Tetrahedron Lett., 1991, 32, 2995.

 

  1. Daniel L. Comins and Hao Hong, “Chiral Dihydropyridones as Synthetic Intermediates. Asymmetric Synthesis of (+)‑Elaeokanine A and (+)‑Elaeokanine C,” J. Am. Chem. Soc., 1991, 113, 6672.

 

  1. Daniel L. Comins and Ali Dehghani, “N‑Acyldihydropyridones as Synthetic Intermediates. A Short Synthesis of

(±)‑Pumiliotoxin C,” Tetrahedron Lett., 1991, 32, 5697.

 

  1. Daniel L. Comins and Emmanuel Zeller, “N‑Acyldihydropyridones as Synthetic Intermediates. A Short Synthesis of (±)‑Indolizidine 209B,” Tetrahedron Lett., 1991, 32, 5889.

 

  1. Daniel L. Comins and Lawrence A. Morgan, “N‑Acyldihydropyridones as Synthetic Intermediates. Synthesis of

(±)‑Septicine and (±)‑Tylophorine,” Tetrahedron Lett., 1991, 32, 5919.

 

  1. Daniel L. Comins, Hao Hong and James M. Salvador, “An Efficient Asymmetric Synthesis of 1‑Acyl‑2‑alkyl‑1,2‑ dihydropyridines,”  J. Org. Chem., 1991, 56, 7197.

 

  1. Daniel L. Comins and Rima S. Al‑awar, “An Intramolecular Diels‑Alder/retro‑Mannich Approach to the cis‑Perhydroquinoline Ring System.  Model Studies toward the Synthesis of Lycopodium Alkaloids,” J. Org. Chem., 1992, 57, 4098.

 

  1. Daniel L. Comins, “The Synthetic Utility of a-Amino Alkoxides,” Synlett, 1992, 615-625.

 

  1. Rima S. Al-awar, Sajan P. Joseph, and Daniel L. Comins, “Conversion of N-Acyl-2,3-dihydro-4-pyridones to 4-Chloro-1,2-dihydropyridines using the Vilsmeier Reagent,” Tetrahedron Lett., 1992, 33, 7635.

 

  1. Daniel L. Comins and Ali Dehghani, “Pyridine-Derived Triflating Reagents: An Improved preparation of Vinyl Triflates from Metallo Enolates,” Tetrahedron Lett., 1992, 33, 6299.

 

  1. Daniel L. Comins and Donald H. LaMunyon, “Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates. Asymmetric Synthesis of the Quinolizidine Alkaloids, (+)-Myrtine, (-)-Lasubine I, and (+)-Subcosine I,” J. Org. Chem., 1992, 57, 5807.

 

  1. Daniel L. Comins, Matthew F. Baevsky, and Hao Hong, “A Ten-Step, Asymmetric Synthesis of (S)-Camptothecin,” J. Am.Chem. Soc., 1992, 114, 10,971.

 

  1. Daniel L. Comins and Michael O. Killpack, “The Stereoselective Addition of Triphenylsilylmagnesium Bromide to Chiral 1-Acyl-4-methoxypyridinium Salts. Synthesis and Reactions of Enantiopure 1-Acyl-2-(triphenylsilyl)-2,3-dihydro-4-pyridones,” J. Am. Chem. Soc., 1992, 114, 10,972.

 

  1. Daniel L. Comins and James M. Salvador, “An Efficient Preparation of (+)-trans-2-(a-Cumyl)cyclohexanol ((+)-TCC): A Practical Alternative to (+)-8-Phenylmenthol,” Tetrahedron Lett., 1993, 34, 801.

 

  1. Daniel L. Comins and James M. Salvador, “Efficient Synthesis and Resolution of Trans-2-(1-Aryl-1-methylethyl)-cyclohexanols: Practical Alternatives to 8-Phenylmenthol,” J. Org. Chem., 1993, 58, 4656.

 

  1. Daniel L. Comins and Hao Hong, “Asymmetric Synthesis of (-)-Porantheridine” J. Am. Chem. Soc., 1993, 115, 8851.

 

  1. Daniel L. Comins and Hao Hong, “The Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts. An Asymmetric Synthesis of (-)-Sedamine,” J. Org. Chem., 1993, 58, 5035.

 

  1. Rima S. Al-awar, Sajan P. Joseph, and Daniel L. Comins, “Conversion of N-Acyl-2,3-dihydro-4-pyridones to 4-Chloro-1,2-dihydropyridines Using the Vilsmeier Reagent. Synthesis of (-)-Coniine and (±)-Lupinine,” J. Org. Chem., 1993, 58, 7732.

 

  1. Daniel L. Comins and Ali Dehghani, “A Short, Asymmetric Synthesis of (-)-Pumiliotoxin C,” J. Chem. Soc., Chem. Commun., 1993, 1838.

 

  1. Phirtu Singh, Daniel L. Comins, and Sajan P. Joseph, “4-Methoxy-1-[(1R,4S,5R)-8-phenylmenthoxycarbonyl]-pyridinium hexachloroantimonate,” Acta Cryst., 1994, C50, 25.

 

  1. Daniel L. Comins, Geewon Chung, and Michael A. Foley, “Regio- and Stereoselective Addition of Nucleophiles to 1-(Phenoxycarbonyl)-2,3-dihydropyridinium Salts,” Heterocycles, 1994, 37, 1121.

 

  1. Daniel L. Comins and Nezha Radi Benjelloun, “Enantiopure N-Acyldihydropyridones as Synthetic Intermediates. An Asymmetric Synthesis of Solenopsin A,” Tetrahedron Lett., 1994, 35, 829.

 

  1. Daniel L. Comins and Gao Jianhua, “N– vs. O-Alkylation in the Mitsunobu reaction of 2-Pyridone,” Tetrahedron Lett. 1994, 35, 2819.

 

  1. Daniel L. Comins, Sajan P. Joseph, and R. Richard Goehring, “Asymmetric Synthesis of 2-Alkyl(Aryl)-2,3-dihydro-4-pyridones by Addition of Grignard Reagents to Chiral 1-Acyl-4-methoxypyridinium Salts,” J. Am. Chem. Soc. 1994, 116, 4719.

 

  1. Daniel L. Comins, Hao Hong, and Gao Jianhua, “Asymmetric Synthesis of Camptothecin Alkaloids: A Nine-Step Synthesis of (S)-Camptothecin,” Tetrahedron Lett. 1994, 35, 5331.

 

  1. Daniel L. Comins, Hao Hong, Jayanta Saha, and Gao Jianhua, “A 6-Step Synthesis of (±)-Camptothecin,” J. Org. Chem., 1994, 59, 5120.

 

  1. Daniel L. Comins, Lourdes Guerra-Weltzien and James M. Salvador, “A Practical Preparation of Cyclohexyl-Based Chiral Auxiliaries from Limonene Oxide,” Synlett, 1994, 972.

 

  1. Sajan P. Joseph, Daniel L. Comins and Phirtu Singh. “An Unusual C-4a Hydroxylated Decahydroquinolone,” Acta Cryst. 1994, C50, 950.

 

  1. Daniel L. Comins and Donald H. LaMunyon “Grignard Addition to 1-Acyl Salts of Chiral 4-Alkoxypyridines. A New Enantioselective Preparation of 2-Alkyl-2,3-dihydro-4-pyridones,” Tetrahedron Lett., 1994, 35, 7343.

 

  1. Daniel L. Comins and Xiaoling Zheng, “A Novel Approach to the Perhydrohistrionicotoxin Ring System,” Chem. Soc., Chem. Commun., 1994, 2681.

 

  1. Daniel L. Comins and Rima S. Al-awar, “Model Studies Toward the Synthesis of the Lycopodium Alkaloid, Phlegmarine,” Org. Chem., 1995, 60, 711.

 

  1. Daniel L. Comins and Ali Dehghani, “Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: The First Asymmetric Synthesis of trans-Decahydroquinoline Alkaloid (+)-219A”, J. Org. Chem., 1995, 60, 794.

 

  1. Christopher J. Foti and Daniel L. Comins, “Synthesis and Reactions of a-[(Trifluoromethylsulfonyl) oxy]enecarbamates Prepared from N-Acyllactams,” J. Org. Chem., 1995, 60, 2656.

 

  1. Daniel L. Comins and Jayanta K. Saha, “Asymmetric Synthesis of a Key Camptothecin Intermediate from 2-Fluoropyridine,” Tetrahederon Lett., 1995, 36,

 

  1. Daniel L. Comins, Sajan P. Joseph and Xinghai Chen, “Regiospecific Substitution of N-Acyl-2,3-dihydro-4-pyridones at C-5 via Halogenation and Cross-Coupling, “Tetrahedron Lett., 1995, 36,

 

  1. Daniel L. Comins, Sajan P. Joseph and David D. Peters, “Preparation of 2,6-Disubstituted 2,3-Dihydro-4-pyridones: Dehydrogenation of Trimethylsilyl Enol Ethers with Palladium (II) Acetate,” Tetrahedron Lett., 1995, 36,

 

  1. Hao Hong and Daniel L. Comins, “A Three-Step Synthesis of Cerpegin, “ Org. Chem. 1996, 61, 391.

 

  1. Daniel L. Comins, Sajan P. Joseph and Yue-mei Zhang,” Regio- and Stereoselective Intramolecular Heck Reactions of N-Acyl-2,3-dihydro-4-pyridones,” Tetrahedron Lett., 1996, 37,

 

  1. Daniel L. Comins and Lourdes Guerra-Weltzien, “Asymmetric Addition of Grignard Reagents to Chiral 1-Acylpyridinium Salts: A Chiral Auxiliary Study,” Tetrahedron Lett., 1996, 37,

 

  1. Daniel L. Comins, Ali Dehghani, Christopher J. Foti, and Sajan P. Joseph, “Pyridine-Derived Triflating Reagents: N-(2-Pyridyl)triflimide and N-(5-Chloro-2-pyridyl)triflimide,” Org. Synth., 1996, 74, 77.

 

  1. Daniel L. Comins and Yue-mei Zhang, “Anionic Cyclizations of Chiral 2,3-Dihydro-4-pyridones: A 5-Step, Asymmetric Synthesis of Indolizidine 209D,” J. Am. Chem. Soc., 1996, 118, 12248.

 

  1. Daniel L. Comins and Jayanta K. Saha, “A Concise Synthesis of Mappicine Ketone and (±)-Mappicine,” J. Org. Chem., 1996, 61, 9623.

 

  1. Daniel L. Comins, Xinghai Chen and Sajan P. Joseph, “Synthesis of 2,4-Disubstituted N-Acyl-5,6-dihydro-2-pyridones,” Tetrahedron Lett., 1996, 37, 9275.

 

  1. Daniel L. Comins* and Xiaoling Zheng, “A Formal Synthesis of Perhydrohistrionicotoxin,” ECHET96: Electronic Conference on Heterocyclic Chemistry, 1996, Contribution 114.

 

  1. Daniel L. Comins and Sajan P. Joseph, “N,N-Dimethylformamide, N-Methylformanilide, N-Formylpiperidine, 2-(N-Formyl-N-Methyl)aminopyridine, Lithium morpholide, N-Lithio-N, N¢,N¢-trimethylenthylenediamine and Lithium N-methylpiperazide,” in Encyclopedia of Reagents for Organic Synthesis, L.A. Paquette, Ed.; Wiley, 1996.

 

  1. Daniel L. Comins and Sajan P. Joseph, “Chemistry of Pyridines at Ring Positions,” in Comprehensive Heterocyclic Chemistry: Second Edition, Vol. 5, A. McKillop, Ed. Pergamon Press, Oxford, England, 1996.

 

  1. Daniel L. Comins and Sajan P. Joseph, “Dihydropyridones as Building Blocks for Alkaloid Synthesis,” in Advances in Nitrogen Heterocycles, Vol. 2, C.J. Moody, Ed., JAI Press, Greenwich, Connecticut, 1996.

 

  1. Daniel L. Comins, Sajan P. Joseph, Hao Hong, Rima S. Al-awar, Christopher J. Foti, Yue-mei Zhang, Xinghai Chen, Donald H. LaMunyon and Maria Guerra-Weltzien, “Asymmetric Synthesis and Synthetic Utility of 2,3-Dihydro-4-pyridones,” Pure and Applied Chem., 1997, 69, 477.

 

  1. Daniel L. Comins, Paresh M. Thakker, Matthew F. Baevsky, and Mohammed M. Badawi, “Chiral Auxiliary Mediated Pictet-Spengler Reactions: Asymmetric Syntheses of (-)-Laudanosine, (+)-Glaucine and (-)-Xylopinine,” Tetrahedron 1997, 53, 16327.
  1. Daniel L. Comins and Sean O’Connor, “Six-Membered Ring Systems: Pyridine and Benzo Derivatives,” in Progress in Heterocyclic Chemistry, Vol. 9, H. Suschitzky and G. W. Gribble, Eds.; Pergamon Press, Oxford, England, 1997.

 

  1. Daniel L. Comins, Xinghai Chen and Lawrence A. Morgan, “Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (-)-Septicine and (-)-Tylophorine,” J. Org. Chem., 1997, 62, 7435.

 

  1. Daniel L. Comins, Donald H. LaMunyon, and Xinghai Chen, “Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of Indolizidine Alkaloids (-)-205A, (-)-207A, and  (-)-235B,” J. Org. Chem., 1997, 62, 8182.

 

  1. Daniel L. Comins, Chris J. Foti and Adam H. Libby, “Model Studies Toward the Synthesis of N-Acetyl-Nb-methyl   phlegmarine: Addition of Cyclohexylmethyl Organometallics to 1-Acylpyridinium Salts,”  Heterocycles, 1998, 48, 1313.

 

  1. Daniel L. Comins, Yong Sup Lee and Paul D. Boyle, “Intramolecular Photocycloaddition of a Tethered Bis-2,3-dihydro-4- pyridone: Stereochemistry and Reactivity of the Cycloadduct,” Tetrahedron Lett., 1998, 39, 187.

 

  1. Daniel L. Comins, David A. Stolze, Paresh Thakker and Cheryl L. McArdle, “C-3 Acetoxylation of N-Acyl 1-2,3-dihydro-4-pyridones,” Tetrahedron Lett., 1998, 39, 5693.

 

  1. Daniel L. Comins, Yue-mei Zhang and Xiaoling Zheng, “Photochemical Reactions of Chiral 2,3-Dihydro-4(1H)-pyridones: Asymmetric Synthesis of (-)-Perhydrohistrionicotoxin,” J. Chem. Soc., Chem. Commun., 1998, 2509.

 

  1. Daniel L. Comins and Gary M. Green, “Asymmetric Synthesis of Dienomycin C,” Tetrahedron Lett., 1999, 40, 217.

 

  1. Daniel L. Comins, Adam H. Libby, Rima S. Al-awar and Christopher J. Foti, “Asymmetric Synthesis of the Lycopodium Alkaloid, Na-Acetyl-Nb-methylphlegmarine,” J. Org. Chem. 1999, 64, 2184.

 

  1. Daniel L. Comins, Jeffrey T. Kuethe, Hao Hong and Frederick J. Lakner, “Diastereoselective Addition of Prochiral Metallo Enolates to Chiral 1-Acylpyridinium Salts,” J. Am. Chem. Soc., 1999, 121, 2651.

 

  1. Daniel L. Comins, Clinton A. Brooks, Rima S. Al-awar and R. Richard Goehring, “IMDA/Retro-Mannich Approach to cis-Perhydroquinoline Lycopodium Alkaloids: Asymmetric Synthesis of (+)-Luciduline,” Org. Lett. 1999, 1, 229.

 

  1. Daniel L. Comins, Yue-mei Zhang and Sajan P. Joseph, “Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of Benzomorphans,” Org. Lett. 1999, 1, 657.

 

  1. Jeffrey T. Kuethe and Daniel L. Comins, “The Mukaiyama-Michael Reaction of N-Acyl-2,3-dihydro-4-pyridones: Regio-and Stereoselective Synthesis of cis-2,6-Disubstituted 1,2,5,6-Tetrahydropyridines,” Org. Lett. 1999, 1, 1031.

 

  1. Daniel L. Comins and Alan B. Fulp, “Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (-)-Slaframine,” Org. Lett. 1999, 1, 1941.

 

  1. Daniel L. Comins, “Asymmetric Synthesis and Synthetic Utility of 2,3-Dihydro-4-pyridones,” J. Heterocyclic Chem. 1999, 36, 1491.