2000 – 2009

  1. Daniel L. Comins and Alfred L. Williams, “Asymmetric Synthesis of Erythro- and Threo-2-(1-hydroxyalkyl)piperidines via Iodocyclocarbamation of 1-Acyl-2-alkenyl-1,2,3,6-tetrahydropyridines,” Tetrahedron Lett. 2000, 41, 2839.

 

  1. Jeffrey T. Kuethe and Daniel L. Comins, “Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts: Total Synthesis of (+)-Cannabisativine,” Org. Lett. 2000, 2, 855.

 

  1. Shenlin Huang and Daniel L. Comins, “Total Synthesis of (+)-Streptazolin,” J. Chem. Soc., Chem. Commun., 2000, 7, 569.

 

  1. Clinton A. Brooks and Daniel L. Comins, “Asymmetric Synthesis of (2S, 4R)-4-Hydroxypipecolic Acid,” Tetrahedron Letters, 2000, 41, 3551.

 

  1. Daniel L. Comins, Clinton A. Brooks, and Charles L. Ingalls, “Reduction of N-Acyl-2,3-dihydro-4-pyridones using Zinc/Acetic Acid,” J. Org. Chem., 2001, 66, 2181.

 

  1. Daniel L. Comins, Shenlin Huang, Cheryl L. McArdle and Charles L. Ingalls, “Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates: A Concise Asymmetric Synthesis of (+)-Allopumiliotoxin 267A,” Org. Lett., 2001, 3, 469.

 

  1. Daniel L. Comins, Anne-Cécile Hiebel and Shenlin Huang, “Synthesis and Reactivity of N-Acyl-5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones,” Org. Lett., 2001, 3, 769.

 

  1. Daniel L. Comins and Christian G. Ollinger, “Inter- and Intramolecular Horner-Wadsworth-Emmons Reactions of 5- (Diethoxyphosphoryl)-1-acyl-2-alkyl(aryl)-2,3-dihydro-4-pyridones,” Tetrahedron Lett., 2001, 42, 4115.

 

  1. Daniel L. Comins, Matthew J. Sandelier, and Teresa Abad Grillo, “Asymmetric Synthesis of (+)-Desoxoprosopinine,” Org. Chem. 2001, 66, 6829.

 

  1. Daniel L. Comins and Alan B. Fulp, “Enantiopure 2,3-Dihydro-4-pyridones as Synthetic Intermediates: Asymmetric Synthesis of 1-Deoxynojirimycin,” Tetrahedron Lett. 2001, 42, 6839.

 

  1. Daniel L. Comins and Alfred L. Williams, “Model Studies Toward the Total Synthesis of the Lycopodium Alkaloid, Spirolucidine,” Lett., 2001, 3, 3217.

 

  1. Daniel L. Comins and Jason M. Nolan, “A Practical 6-Step Synthesis of (S)-Camptothecin,” Lett. 2001, 3, 4255.

 

  1. Alfred L. Williams, Teresa Abad Grillo and Daniel L. Comins, “A Novel Free Radical Ring Contraction of a Cyclic Carbamate,” Org. Chem., 2002, 67, 1972.

 

  1. Daniel L. Comins, Xiaoling Zheng and R. Richard Goehring, “Total Synthesis of the Putative Structure of the Lupin Alkaloid, Plumerinine,” Lett., 2002, 4, 1611.

 

  1. Daniel L. Comins, Michael O. Killpack, Emilie Despagnet and Emmanuel Zeller, “Synthesis and Reactions of Enantiopure 1-Acyl-2-(triaryl(alkyl)silyl)-2,3-dihydro-4-pyridones,” Heterocycles 2002, 58, 505.

 

  1. Sajan Joseph and Daniel L. Comins, “Synthetic Applications of Chiral 2,3-Dihydro-4-pyridones,” Current Opinion in Drug Discovery and Development, 2002, 5, 870-880.

 

  1. Jeffrey T. Kuethe, Clinton A. Brooks and Daniel L. Comins*, “Diels-Alder Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: Regio-and Stereoselective Synthesis of Octahydroquinolines,” Org. Lett., 2003, 5, 321.

 

  1. Jeffrey T. Kuethe and Daniel L. Comins, “Tandem Diels-Alder Cyclization/Aromatization Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones,” Tetrahedron Lett. 2003, 44, 4179.

 

  1. Jason M. Nolan and Daniel L. Comins, “Regioselective Sonogashira Couplings of 2,4-Dibromoquinolines. A Correction”, Org. Chem., 2003, 68, 3736.

 

  1. Jeffrey T. Kuethe and Daniel L. Comins, “Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts,” Org. Chem., 2004, 69, 2863.

 

  1. Jeffrey T. Kuethe and Daniel L. Comins, “Asymmetric Total Synthesis of (+)-Cannabisativine,” J. Org. Chem., 2004, 69, 5219. .

 

  1. Dimitar B. Gotchev and Daniel L. Comins, “Novel Heterocyclic Systems. Synthesis of 2,7-Dimethyl-10-oxa-1,8-diaza-anthracen-9-one and Derivatives,” Tetrahedron 2004, 60, 11751.

 

  1. Daniel L. Comins, Sean O’Connor, and Jason Dinsmore, “Six-Membered Ring Systems: Pyridine and Benzo Derivatives,” in Progress in Heterocyclic Chemistry, Vol. 16, G. W. Gribble and J. A. Joule, Eds.; Pergamon Press, Oxford, England, 2004.

 

  1. Daniel L. Comins, Stefan Schilling and Yanchen Zhang, “Asymmetric Synthesis of 3-Substituted Isoindolinones: Application to the Total Synthesis of (+)-Lennoxamine,” Org. Lett., 2005, 7, 95.

 

  1. Daniel L. Comins, Jeffrey T. Kuethe, Teresa M. Miller, Florence C. Février, and Clinton A. Brooks, “Diels-Alder Reactions of N-Acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones,” J. Org. Chem., 2005, 70, 5221.

 

  1. Daniel L. Comins and Anne-Cécile Hiebel, “Asymmetric Synthesis of 3,3-Disubstituted Isoindolinones,” Tetrahedron Lett., 2005, 46, 5639.

 

  1. Daniel L. Comins, Jason M. Nolan and Ibrahim D. Bori, “Regioselective Lithium-Halogen Exchange and Palladium- catalyzed Cross-Coupling Reactions of 2,4-Dihaloquinolines,” Tetrahedron Lett. 2005, 46, 6697.

 

  1. Daniel L. Comins, Laura S. King, Emilie D. Smith, and Florence C. Février, “Synthesis of C-4 Substituted Nicotine Derivatives via an N-Acylpyridinium Salt of (S)-Nicotine,” Org. Lett., 2005, 7, 5059.

 

  1. Daniel L. Comins and James J. Sahn, “A Six-Step Synthesis of (+)-Hyperaspine,” Org. Lett. 2005, 7, 5227.

 

  1. Florence C. Février, Emilie D. Smith, and Daniel L. Comins, “Regioselective C-2 and C-6 Substitution of (S)-Nicotine and Nicotine Derivatives,” Org. Lett. 2005, 7, 5457.

 

  1. Damian W. Young and Daniel L. Comins, “Tandem Directed Lithiations of N-Boc-1,2-dihydropyridines toward Highly Functionalized 2,3-Dihydro-4-pyridones,” Org. Lett. 2005, 7, 5661.

 

  1. Emilie D. Smith, Florence C. Février and Daniel L. Comins, “Synthesis of Nicotine Derivatives via Reductive Disilylation of (S)-Nicotine,” Org. Lett. 2006, 8, 179.

 

  1. Daniel L. Comins and Emilie D. Smith, “A Six-Step Synthesis of (S)-5-Ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB- 1508Y) from (S)-Nicotine,” Tetrahedron Lett. 2006, 47, 1449.

 

  1. Florence F. Wagner and Daniel L. Comins, “Regioselective Substitution at the C-5, C-4 and C-2 Positions of (S)-6- Chloronicotine and C-4 Substitution of (S)-5-Chloronicotine,” Eur. J. Org. Chem. 2006, 3562.

 

  1. Florence F. Wagner and Daniel L. Comins, “Six-Step Synthesis of (S)-Brevicolline from (S)-Nicotine,” Org. Lett. 2006, 8, 3549.

 

  1. Dimitar B. Gotchev and Daniel L. Comins, “Synthetic Studies Toward (-)-FR901483 Using a Conjugate Allylation to Install the C-1 Quaternary Carbon,” J. Org. Chem. 2006, 71, 9393.

 

  1. Florence F. Wagner and Daniel L. Comins, “Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine,” J. Org. Chem. 2006, 71, 8673.

 

  1. Christof F. Stumpf, Daniel L. Comins, Thomas C. Sparks, Kevin V. Donohue, and R. Michael Roe, “Insecticidal activity and mode of action of novel neonicotinoids synthesized by new acylpyridinium salt chemistry and directed lithiation,” Pesticide Biochemistry and Physiology, 2007, 87, 211.

 

  1. Jennifer L. Frahm, Ibrahim D. Bori, Daniel L. Comins, Adam M. Hawkridge and David C. Muddiman, “Achieving Augmented Limits of Detection for Peptides with Hydrophobic Alkyl Tags (ALiPHAT),” Anal. Chem. 2007, 79, 3989.

 

  1. Florence F. Wagner and Daniel L. Comins, “Recent Advances in the Synthesis of Nicotine and its Derivatives,” Tetrahedron 2007, 63, 8065.

 

  1. Daniel L. Comins, Jason M. Dinsmore, and Lucas R. Marks, “One-pot Terminal Alkene Homologation using a Tandem Olefin Cross Metathesis/Allylic Carbonate Reduction Sequence,” Chem. Commun. 2007, 4170.

 

  1. Daniel L. Comins and Kazuhiro Higuchi, “Synthesis of Benzo-fused Indolizidine Alkaloid Mimics,” Beil. J. Org. Chem. 2007, 3:42.

 

  1. Pauline W. Ondachi and Daniel L. Comins, “Synthesis and Regioselective Substitution of C-6 Alkoxy Derivatives of (S)-Nicotine,” Tetrahedron Lett. 2008, 49, 569.

 

  1. Pandi Bharathi and Daniel L. Comins, “Asymmetric Synthesis of C2-Symmetric Vicinal Diamines via Reductive Dimerization of N-Acylpyridinium and Related Salts,” Org. Lett. 2008, 10, 221.

 

  1. Williams, D. Keith, Jr., Corey W. Meadows, Ibrahim D. Bori, Adam M. Hawkridge, Daniel L. Comins, and David C. Muddiman, “Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy,” J. Am. Chem. Soc. 2008, 130, 2122.

 

  1. Dorit Eliyahu, Satoshi Nojima, Sonja S. Capracotta, Daniel L. Comins and Coby Schal, “Identification of Cuticular Compounds Responsible for Eliciting Interspecific Courtship Behavior in the Male German Cockroach, Blattella germanica,” Naturwissenschaften, 2008, 95, 403.

 

  1. Daniel L. Comins, Sean O’Connor, Rima S. Al-Awar, Pyridines and their Benzo Derivatives: Reactivity at the Ring. In Comprehensive Heterocyclic Chemistry III, A. R. Katritzky, C. A. Ramsden, EFV Scriven and RJK Taylor, Eds.; Elsevier: Oxford, 2008; Vol. 7, pp 41-100.

 

  1. W. Stephen McCall, Teresa Abad Grillo and Daniel L. Comins, “Stereoselective Synthesis of Acyclic Amino Alcohols via von Braun Ring Opening of Chiral Piperidines,” Org. Lett., 2008, 10, 3255.

 

  1. W. Stephen McCall, Teresa Abad Grillo and Daniel L. Comins, “N-Acyldihydropyridones as Synthetic Intermediates. A Stereoselective Synthesis of Acyclic Amino Alcohols Containing Multiple Chiral Centers,” J. Org. Chem. 2008, 73, 9744.

 

  1. Sonja S. Capracotta and Daniel L. Comins, “Chiral Amino Alcohols Derived from (S)-6-Chloronicotine as Catalysts for Asymmetric Synthesis,” Tetrahedron Lett. 2009, 50, 1806.

 

  1. W. Stephen McCall and Daniel L. Comins, “Synthesis of 1,3-Amino Alcohol Derivatives via a Silicon-mediated Ring Opening of Substituted Piperidines,” Org. Lett., 2009, 11, 2940.

 

  1. D. Keith Williams Jr., Daniel L. Comins, Jerry L. Whitten, and David C. Muddiman, “Evaluation of the ALiPHAT Method for PC-IDMS and Correlation of Limits-of-Detection with Nonpolar Surface Area,” J. Am. Soc. Mass. Spectrom., 2009, 20, 2006.